Shieldin complex assembly kinetics and dna binding by shld3

HIGHLIGHTS

• who: Vivek Susvirkar from the (UNIVERSITY) have published the article: Shieldin complex assembly kinetics and DNA binding by SHLD3, in the Journal: (JOURNAL) of 28/09/2022
• what: The authors show that this which lacks the SHLD2 binding domain is able to bind to a variety of substrates non-discriminatorily. Taken together the authors show that the can contain a conformationally asymmetric REV7 dimer that requires one u2018closed` REV7 bound to SHLD3 and a second REV7 molecule that can adopt any conformation to mediate the interaction with SHLD2 to the static core of REV7. Since . . .
  

   

  

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