HIGHLIGHTS
- who: Zhenzhen Guo and collaborators from the College, Henan University, Kaifeng, China have published the research: Shikonin as a WT1 Inhibitor Promotes Promyeloid Leukemia Cell Differentiation, in the Journal: Molecules 2022, 8264 of 26/Nov/2022
- what: This study proved the suppressing effect of shikonin on WT1 in protein expression and function and suggested that: (1) shikonin can down-regulate the WT1 protein level for leukemia differentiation therapy, and (2) the interaction between WT1 and CD34 proteins may be responsible for granulocyte/monocyte immaturity in HL-60 cells.
- future: Although further investigations in . . .
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