Shld1 is dispensable for 53bp1-dependent v(d)j recombination but critical for productive class switch recombination

HIGHLIGHTS

• who: Estelle Vincendeau from the Université University of QN, UK have published the Article: SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: In agreement with this, the authors show that 53BP1 knockout splenic B cells have a CSR defect approximately twice as severe as SHLD1 knockout splenic B cells, possibly illustrating the dual property of 53BP1. The authors show that SHLD1 does not promote long-range V(D)J recombination, that is thought to rely on the ability . . .
  

   

  

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