Short chain dehydrogenase/reductase rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development*

HIGHLIGHTS

• who: Olga V. Belyaeva from the as the source of retinaldehyde for a yet unidentified retinaldehyde dehydrogenaseFrog rdhe, has two homologs in mammals, one of which, (SDR, ), is known to recognize all-trans-retinol as a substrate with NAD⫹ as the preferred cofactor, which suggests that it functions in the oxidative direction in the cells. As shown in this study, the second mammalian homolog, RDHE S (SDR, ), also exhibits an oxidative all-trans-retinol dehydrogenase activity when expressed in living cells. Compared with rdhe2, the mammalian homologs appear to have lower activities, but this could be due . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.