Short communication

HIGHLIGHTS

• who: Short communication and collaborators from the LaboratoryUniversity of have published the research work: Short communication, in the Journal: (JOURNAL)
• what: The authors report that brequinar (BQR), which is a specific inhibitor of dihydroorotate dehydrogenase, robustly inhibits ASFV replication in Vero cells, as well as in porcine macrophages. The authors demonstrate that BQR exerts its antiviral activity in a dosedependent manner through the depletion of pyrimidine pool. The authors evaluated the antiviral activity of DHODH and IMPDH inhibitors against ASFV.
• how: To further validate whether the potent anti-ASFV activity of BQR was . . .
  

   

  

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