Short-form ron is a novel determinant of ovarian cancer

HIGHLIGHTS

  • who: Top from the Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA have published the Article: Short-form Ron is a novel determinant of ovarian cancer, in the Journal: (JOURNAL)
  • what: The authors report the striking discovery that sfRon expression is required for development of carcinogen-induced malignant ovarian tumors in mice. The authors report that introduction of sfRon into OVCAR3 cells resulted in epithelial-to-mesenchymal transition activation of the PI3K and PDK1 pathway and inhibition of the MAPK pathway. The authors show . . .

     

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