HIGHLIGHTS
- who: Guo-Liang Chew from the National University have published the research: Short H2A histone variants are expressed in cancer, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Through comparative analyses of germline short H2A sequences and oncohistone mutations in canonical H2A, the authors show that short H2As inherently possess oncohistone features. The authors explore several cancer data sets and find H2A.B expression in a diverse array of malignancies. The authors propose that the nucleosomedestabilizing characteristics sH2As evolved for their role in testis result in oncohistone activity in other tissues. The authors focused on . . .
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