Short o-glcnacase is targeted to the mitochondria and regulates mitochondrial reactive oxygen species level

HIGHLIGHTS

  • who: Patrick Pagesy and collaborators from the Universitu00e9 de Nantes, CHU Nantes, Inserm, CNRS, SFR Santu00e9, INSERM UMS, CNRS UMS , have published the article: Short O-GlcNAcase Is Targeted to the Mitochondria and Regulates Mitochondrial Reactive Oxygen Species Level, in the Journal: Cells 2022, 11, 1827. of /2022/
  • what: In this work using cell fractionation experiments the authors show that short-OGA is preferentially recovered in mitochondriaenriched fractions from HEK-293T cells and RAW 264.7 cells as well as mouse embryonic fibroblasts. Using a Bioluminescence Resonance Energy Transfer (BRET)-based O-GlcNAcylation biosensor the . . .

     

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