Shp-2 and pd-1-shp-2 signaling regulate myeloid cell differentiation and antitumor responses

HIGHLIGHTS

• who: Anthos Christofides from the (UNIVERSITY) have published the research work: SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses, in the Journal: (JOURNAL) of 23/Dec/2021
• what: Combined approaches of SHP-2 allosteric inhibitors and pharmacologic RTK inhibitors or KRASG12C-GDP inhibitors have been employed with the main purpose to target signaling vulnerabilities in cancer50.
• how: These results indicated that PD-1-SHP-2 signaling suppressed HOXA10 and IRF8 phosphorylation which have important roles in myeloid differentiation and lineage fate commitment913. These results showed that . . .
  

   

  

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