HIGHLIGHTS
- who: Clive Bate from the (UNIVERSITY) have published the research work: Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses*, in the Journal: (JOURNAL) of August/12,/2016
- what: The authors demonstrate that the targeting of PrPC to synapses was dependent upon cholesterol concentrations in the recipient neurons. More specifically, the authors show that the presence of sialic acid on the GPI anchor is necessary for the targeting of PrPC to synapses.
SUMMARY
PrPC is found within cholesterol-rich, membrane microdomains that are commonly called lipid rafts . . .
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