Sialofucosylation enables platelet binding to myeloma cells via p-selectin and suppresses nk cell-mediated cytotoxicity

HIGHLIGHTS

• who: Alessandro Natoni et al. from the Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy have published the research: Sialofucosylation Enables Platelet Binding to Myeloma Cells via P-Selectin and Suppresses NK Cell-Mediated Cytotoxicity, in the Journal: Cancers 2023, 2154 of /2023/
• what: The authors showed that the presence of induced a strong binding of MM cells to leading to specific and direct interactions with platelets which could be inhibited by a P-selectin-blocking antibody. The authors show that MM cells enriched in SLea/x bind to platelets in BM . . .
  

   

  

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