HIGHLIGHTS
- who: Xue-min Gao from the (UNIVERSITY) have published the paper: Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis, in the Journal: (JOURNAL)
- what: Mutations that cause continuous MAPK pathway activation play a fundamental role in the pathogenesis of Langerhans cell histiocytosis, affecting processes including proliferation, functional attenuation, entrapment, and inflammatory background formation.
- future: Experiments are needed to evaluate the CCR7 expression level in human LCH lesions.
SUMMARY
Independent of the BRAF mutation state, the number of C D4+ T_cells was significantly larger than that of C . . .
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