HIGHLIGHTS
SUMMARY
Recent studies have suggested that circulating cf-DNA levels can be found elevated in various conditions, such as cancer, chronic inflammation, aging, diabetes_mellitus, tissue trauma, sepsis, myocardial infarction or even in physiological nonmalignant conditions, such as those caused by exercise. Interestingly, the authors have already reviewed the promising and intriguing interplay among HBV, hepatocellular senescence and apoptosis, and this consequently led the authors to try to further investigate biomarkers related to apoptosis and senescence, such as circulating cf-DNA and DNA methylation as already mentioned, in serum samples from chronic HBV patients. As a . . .
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