Silencing of the ca2+ channel orai1 improves the multi-systemic phenotype of tubular aggregate myopathy (tam) and stormorken syndrome (strmk) in mice

HIGHLIGHTS

• who: Roberto Silva-Rojas and colleagues from the Mice were housed in ventilated cages with , h day/night cycles and access to food and water ad libitumStim R W/+ and Orai1+/- mice were described previously [21, ], and the Orai1+/- mice were a kind gift from Paul F. Worley (Johns Hopkins University, Baltimore, MD, USA). Crossing of both mouse lines resulted in four genotypes: WT, Orai1+/-, Stim R W/+, and Stim R W/+ Orai1+/- . Owing to the more pronounced muscle weakness in males compared with female Stim R W/+ mice, only males were used in the study. All . . .
  

   

  

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