Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing siah1-mediated mitophagy

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• who: Jing Zhou from the HCC xenograft experiment The HCC xenograft experiment was approved by the Guangxi Medical University Institutional Animal Care and Use Committees (#201910029) and performed according to the Association for Assessment and Accreditation of Laboratory Animal Care guidelinesA total of , male BALB/c nude mice were purchased from Hunan SJA Laboratory Animal Co [, ]. Ltd. (Changsha, China) and housed in an SPF laboratory with free access to food and water. Five million Huh, cells were inoculated subcutaneously into the right flanks of nude mice. Once the inoculated tumor size reached, mm3, the mice were randomly . . .
  

   

  

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