Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

HIGHLIGHTS

  • who: Ignasius Joanito from the (UNIVERSITY) have published the research work: Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer, in the Journal: (JOURNAL)
  • what: Of the 373,058 single cells profiled, the authors focused primarily on the 49,155 epithelial_cells (Fig 1). Putting these together, the authors propose a refinement of the four-group bulk CMS classification, based on the three biological layers of intrinsic epithelial status (I), microsatellite status (M) and presence of fibrosis (F), termed u2018IMF`.
  • how: As . . .

     

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