Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during trypanosoma brucei infection

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SUMMARY

    Overall, the authors identified 11 clusters spanning 8 cell types, including microglia (clusters 0, 1, 6, and 9), oligodendrocytes/B cells (cluster 7), astrocytes (clusters 2 and 5), T_cells (cluster 3), and vascular-associated cells including endothelium (cluster 4), pericytes (cluster 8), and ependymocytes (cluster 10) (Fig 1D and Supplementary Data 2 and 3). Disease state analysis revealed differential distribution of cells within the microglia, B cell, and T_cell clusters in infected samples compared to naïve controls (Fig 1F). The authors did not include cells within the IAMNP subclusters Nature Communications | 13:5752 . . .

     

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