Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance

HIGHLIGHTS

• who: Sameera Zia from the Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada have published the paper: Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance, in the Journal: (JOURNAL)
• what: The authors aimed to dissect the microglial state associated with the cuprizone diet. Given that apoptosis was ongoing during cuprizone consumption (Fig 5h) and that apoptotic carcasses did not accumulate after microglial ablation, the authors reason other phagocytic glial cells support the clearance of apoptotic corpses. As dietary cuprizone kills myelinating oligodendrocytes , the authors aimed . . .
  

   

  

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