Single-cell rna sequencing shows the immune cell landscape in the kidneys of patients with idiopathic membranous nephropathy

SUMMARY

The authors correlated the cell trajectory analysis with the three CD4+ clusters of naive CD4+ T_cells (TC0), central memory CD4+ T_cells (TC1), and effector memory CD4+ T_cells (TC2) (upper), and three CD8+ clusters of resident memory CD8+ T_cells (TC4), GZMK+ CD8+ T_cells (TC5), and cytotoxic T lymphocyte (TC6) (lower). The authors identified the presence of GZMK+CD8+ T_cells and the transition of CTL to GZMK+CD8 + T_cells. The discovery of three CD8+ T-cell subtypes, which underwent a CTL-to-GZMK +CD8+ T_cell transition, and the abundance of GZMK+CD8+ T_cells in IMN kidney tissue, suggested that . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or E-mail:

If you don't have an account, you can create one here.