HIGHLIGHTS
- who: Shannon Coy from the (UNIVERSITY) have published the research: Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma, in the Journal: (JOURNAL) of 20/07/2021
- what: The authors show that microglia are the predominant source of CD39, while tumor cells principally express CD73. The authors use multiplexed tissue imaging, single-cell RNAsequencing, and tissue mass spectrometry imaging to explore the activity and significance of immunomodulatory purinergic signaling in adult and pediatric high-grade gliomas (HGGs). The authors show that this pathway is regulated by heterogeneous cellular components, including CD39 . . .
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