Single cell transcriptome in aneuploidies reveals mechanisms of gene dosage imbalance

HIGHLIGHTS

• who: Georgios Stamoulis et al. from the University of Lausanne, CHUV, Lausanne, Switzerland have published the Article: Single cell transcriptome in aneuploidies reveals mechanisms of gene dosage imbalance, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 28/02/2019
• what: The authors show that burst-like transcription shapes gene dosage imbalance in trisomies. In agreement with the 2-state burst-like model, the authors provide evidence that, in trisomic cells, the additional allele is independently transcribed, leading to an increased monoallelic expression with respect to the diploid cells, and a significant fraction of trisomic cells . . .
  

   

  

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