Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as hiv-1 vaccine candidates

HIGHLIGHTS

• who: Yi-Nan Zhang from the (UNIVERSITY) have published the article: Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates, in the Journal: (JOURNAL) of 29/03/2023
• what: The authors characterize the biophysical, structural, and antigenic properties of 1c-SApNPs that present the BG505 UFO trimer with wildtype and modified glycans. While the BG505 UFO trimer and its SApNPs (FR, E2p, and I3-01v9) were the focus of this study, a cocktail mixing equal amounts (33 u03bcg/dose) of SApNPs that present clade . . .
  

   

  

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