HIGHLIGHTS
- who: Yuan Ma and collaborators from the Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Technology, Qingdao, China have published the research work: Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human 34 Nicotinic Acetylcholine Receptor, in the Journal: (JOURNAL) of 29/07/2022
- what: In this study the binding mode of Czon1107 to hα3β4 nAChR was investigated using molecular dynamics simulations coupled with mutagenesis studies of the peptide and electrophysiology studies on heterologous hα3β4 nAChRs.
- how: The authors obtained the initial model suggesting Czon1107 is . . .
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