HIGHLIGHTS
- who: Yuan Ma et al. from the Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Technology, Qingdao, China have published the paper: Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human 34 Nicotinic Acetylcholine Receptor, in the Journal: (JOURNAL) of 29/07/2022
- what: In this study the binding mode of Czon1107 to hu03b13u03b24 nAChR was investigated using molecular dynamics simulations coupled with mutagenesis studies of the peptide and electrophysiology studies on heterologous hu03b13u03b24 nAChRs.
- how: The authors obtained the initial model suggesting Czon1107 is mostly distributed in the TMD . . .
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