Single-nucleus rna-sequencing of autosomal dominant alzheimer disease and risk variant carriers

HIGHLIGHTS

  • who: Logan Brase from the Processing of brain tissue samples The Washington University Translational Human Neurodegenerative Research (THuNDR) laboratory, which serves as the Neuropathology Core for the Knight Alzheimer Disease Research Center (Knight ADRC) , have published the article: Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers, in the Journal: (JOURNAL) of 15/03/2023
  • what: The authors report microglia and oligodendrocyte cell Nature Communications | 14:2314 states associated with TREM2 risk variant carriers. The authors show that genetic variants influence cell expression states, and, therefore, could explain some disease heterogeneity . . .

     

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