Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

HIGHLIGHTS

• What: The authors show that IIFCs are the main source of paracrine signals in the fracture environment revealing a crucial paracrine role of this transient IIFC population during fracture healing. The study provides a complete temporal topography of the fracture healing stages and the dynamic response of periosteal SSPCs to injury redefining the knowledge of bone regeneration. The authors show that pSSPC represent a single population that can provide osteoblasts and chondrocytes for bone repair by first generating a common injury-induced fibrogenic cell (IIFC) population that can then engage into osteogenesis and chondrogenesis. The authors show . . .
  

   

  

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