Sirpα-fc fusion protein imm01 exhibits dual anti-tumor activities by targeting cd47/sirpα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

HIGHLIGHTS

• who: Jifeng Yu from the (UNIVERSITY) have published the article: SIRPu03b1-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPu03b1 signal pathway via blocking the u201cdonu2019t eat meu201d signal and activating the u201ceat meu201d signal, in the Journal: (JOURNAL)
• what: The authors report the anti-tumor therapeutic potential of IMM01.

SUMMARY

IMM01 can significantly block the binding of a chimeric SIRPα receptor expressing cell (Jurkat-CSR) to CD47 (Additional file 1: Fig S1A, B, C), inhibits the apoptosis of Jurkat-CSR cells via CD47-Fc (Additional file . . .

 



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