Sirt1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/sv female mice

HIGHLIGHTS

• who: Hanna Artsi from the Northwest University, China have published the Article: SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice, in the Journal: (JOURNAL)
• what: This study shows that global Sirt1 haplo-insufficiency attenuates femoral cortical and trabecular bone mass accrual in female but not male 129/Sv mice, resulting in lower femoral Frontiers in Endocrinology frontiersin.org 10.3389/fendo.2022.1032262 et_al that examined Sirt1 mRNA expression in kidney, lung, liver, heart, and colon in C57BL/6J . . .
  

   

  

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