Sirt1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism

HIGHLIGHTS

• who: Yue Zhang from the Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China have published the article: SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism, in the Journal: (JOURNAL)
• what: The authors focused on mtROS to elucidate how it was regulated by CS in LF and how it contributed to LF activation. The authors aim to investigate whether and how CS increased mitochondrial NOX4 (mtNOX4) and thereby produced more mtROS. The authors focused on SIRT1.
• how: Showed that . . .
  

   

  

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