HIGHLIGHTS
- who: PTTG and colleagues from the Second Military Medical University have published the paper: SIRT1 Suppresses Pituitary Tumor Progression by Downregulating PTTG1 Expression, in the Journal: (JOURNAL)
- what: The authors show that SIRT1 is downregulated in pituitary tumor tissues, and SIRT1 expression inhibited tumor growth. As SIRT1 belonged to class III histone deacetylase family, the authors focused on whether histone acetylation/deacetylation would mediate this regulation.
- how: Above result indicated that promoting SIRT1 activity would inhibit pituitary tumor cell growth and invasion the question remained whether inhibition of SIRT1 activity could increase tumor . . .
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