Sirt3 and sirt5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-coa dehydrogenase

HIGHLIGHTS

  • who: Yuxun Zhang and colleagues from the Department Pediatrics, University Pittsburgh, Children`s Hospital Pittsburgh, Pittsburgh have published the article: SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0122297]. March 26, 2015 of January/12,/2015
  • what: The authors demonstrate that SIRT3 and SIRT5 both target human very long-chain acyl-CoA dehydrogenase (VLCAD) a key fatty acid oxidation enzyme. The authors show that VLCAD binds strongly to cardiolipin and isolated mitochondrial membranes via a domain . . .

     

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