Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

HIGHLIGHTS

• who: Angela H. Guo from the DepartmentUniversity of have published the research work: Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload, in the Journal: Scientific Reports Scientific Reports
• how: This result was consistent with electron flow data where no differences in complex II/SDH activity were observed between mitochondria isolated from TAC hearts (Fig 4C).

SUMMARY

To evaluate sensitivity to cardiac stress, male WT and SIRT5OE littermates between 4-8 months of age were randomly assigned to a sham or TAC operation . . .

 



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