HIGHLIGHTS
SUMMARY
One of the characteristic type 2 immune_responses is intestinal epithelial remodeling8. STAT6 is a well-known transcription factor to mediate type 2 immune_responses following IL4/IL13 activation, playing important roles in the clearance of intestinal parasites and allergic disorders14,15. Sirt6 deletion in IECs leads to impaired tuft cell development and intestinal type 2 immunity Sirt6 floxed mice were crossed with Villin-Cre mice to generate IECspecific Sirt6 knockout mice (IEC-KO, genotype: Sirt6flox/flox;VillinCre) and control mice (LoxP, genotype: Sirt6flox/flox). To test whether Sirt6 ablation altered the epithelial_cell life cycle, the . . .
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