Sirtuin activation as a therapeutic approach against inborn errors of metabolism

HIGHLIGHTS

• who: Jeannette C. Bleeker from the Laboratory Genetic Metabolic Diseases, Academic Medical Center, Meibergdreef, AZ Amsterdam, The Netherlands University Medical Center Utrecht, Lundlaan, have published the research work: Sirtuin activation as a therapeutic approach against inborn errors of metabolism, in the Journal: (JOURNAL)
• what: The authors discuss how sirtuins serve as a promising therapeutic target to restore acylation state and could treat IEMs. In this context the authors examine several pharmacological sirtuin activators such as resveratrol NAD+ precursors and PARP and CD38 inhibitors.
• future: More work is needed to better establish the dynamics . . .
  

   

  

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