Site-selective incorporation of a functional group into lys175 in the vicinity of the active site of chymotrypsin by using peptidyl -aminoalkylphosphonate diphenyl ester-derivatives

HIGHLIGHTS

• who: Shin Ono and colleagues from the Graduate School of Science and Engineering, University of Toyama, Toyama, Toyama, Japan have published the paper: Site-Selective Incorporation of a Functional Group into Lys175 in the Vicinity of the Active Site of Chymotrypsin by Using Peptidyl -Aminoalkylphosphonate Diphenyl Ester-Derivatives, in the Journal: (JOURNAL)
• what: The study showed that the Lys175 chemical modification required the peptidyl phosphonate derivative containing a diphenyl phosphonate moiety with (R)-configuration .
• how: By IEC and LC-MS/MS the results showed that DanE reacted with Csin more effectively than DanD . . .
  

   

  

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