Sivcol nef counteracts serinc5 by promoting its proteasomal degradation but does not efficiently enhance hiv-1 replication in human cd4+ t cells and lymphoid tissue

HIGHLIGHTS

• who: Dorota Kmiec and collaborators from the Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany, Department of Infectious have published the paper: SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue, in the Journal: (JOURNAL) of August/20,/2018
• what: The authors show that the Nef protein of the highly divergent SIVcol lineage infecting mantled guerezas (Colobus guereza) is a potent antagonist of SERINC5 although it lacks the CD4 CD3 and CD28 downmodulation activities exerted by other . . .
  

   

  

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