HIGHLIGHTS
- who: DEPTOR and colleagues from the Italy Third Hospital of Hebei Medical University have published the research: Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR, in the Journal: (JOURNAL)
- what: The authors demonstrate that JMC bones are filled with fat and show a decrease in trabecular bone. The work provides a deep understanding of the molecular mechanism by which DEPTOR regulates skeletal progenitor differentiation. The authors show that DEPTOR interacts with and effects localization of the transcriptional regulator TAZ, implicating DEPTOR in an unappreciated signaling . . .
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