Slc30a10 transporter in the digestive system regulates brain manganese under basal conditions while brain slc30a10 protects against neurotoxicity

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• who: Cherish A. Taylor from the Generation and housing of knockout strains All experiments with mice were approved by the Institutional Animal Care and Use Committee of the University of Texas (Austin, TX)We recently described generation of homozygous floxed Slc30a, mice (Slc30a10fl/fl) in which exon , of Slc30a, was flanked by loxP sites (22). Exon , codes for amino acids, of mouse SLC, which encompass most of the transmembrane domain required for manganese transport (21, ). To briefly summarize here, the targeting vector was electroporated into, ., embryonic stem cells (C BL/ , ⫻ , /SvJae) (22). Germ-line chimeras were crossed . . .
  

   

  

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