Sleeping beauty transposase structure allows rational design of hyperactive variants for genetic engineering

HIGHLIGHTS

• who: Franka Voigt from the Division of Medical Biotechnology, Paul Ehrlich Strasse, Langen, Germany, Max Delbrück Center for Molecular Medicine, Robert Rössle Strasse have published the research: Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 30/03/2016
• what: To facilitate SB's applications here the authors determine the crystal structure of the transposase catalytic domain and use it to model the transposase/transposon end/target complex. The work provides novel insights into SB's mechanism and demonstrates how structure . . .
  

   

  

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