HIGHLIGHTS
- who: Ramdane Igalouzene and collaborators from the CNRS and University, INSERM, Montpellier, France have published the research: SMAD4 TGF-u03b2-independent function preconditions naive CD8+ T_cells to prevent severe chronic intestinal inflammation Tumor Escape Resistance and Immunity, in the Journal: (JOURNAL)
- what: The authors show that contrary to an expected TGF-u03b2-dependent function of SMAD4, SMAD4 in T_cells protects mice from severe chronic intestinal inflammation in a TGF-u03b2-independent manner. The authors show that CD8+ T_cells play a critical role in this microbiota-driven immunopathology. Strategically, the authors focused on genes crucial for . . .
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