Small molecule inhibition of group i p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

HIGHLIGHTS

• who: Christy C Ong from the Additional files Additional file, : Figure S , dysregulation is associated with poor patient outcome in breast cancer. (A) Kaplan-Meier curve for , amplification status in METABRIC breast tumor samples. Amplified is defined as , gene amplification >, copies. Survival differences between patients was statistically significant (P=0.0156). (B) Association of , protein expression with clinical outcome. , immunohistochemistry (IHC) was performed as described previously (Ong and colleagues [29]) using breast cancer tissue microarrays (n=1, ) provided by the University of Nottingham. Staining intensity was scored for replicate cores on a histology score of , to, . Overall . . .
  

   

  

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