Small molecule targeting long noncoding rna gas5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

HIGHLIGHTS

• who: Rekha S. Patel from the Department University of have published the research work: Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model, in the Journal: Scientific Reports Scientific Reports
• how: Indicated that 100 nmol was an optimal dose as the goal is to increase GAS5 to physiological levels and not have sustained over-expression which could be detrimental as observed in certain cu00ad ancers3435. The RNAseq results indicated that toll-like receptor 2 -4 -7 and -8 levels were higher in aged . . .
  

   

  

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