HIGHLIGHTS
- who: Giulietta M. Riboldi from the Keele University, United Kingdom have published the paper: SMN post-translational modifications in spinal muscular atrophy, in the Journal: (JOURNAL)
- what: The authors provide an overview of the PTMs involved in the regulation of the SMN complex functions with a focus on those that have been linked to SMA etiology. This study reported that, in addition to being modified by SUMO-1 and SUMO-2, SMN can interact non-covalently with SUMO through its SIM. This study showed that sumoylation modulates the SMN activities that are relevant for SMA . . .
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