Smurf1 facilitates oxidative stress and fibrosis of ligamentum flavum by promoting nrf2 ubiquitination and degradation

HIGHLIGHTS

• who: Yifei Gu and collaborators from the Department of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China have published the research: Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation, in the Journal: Mediators of Inflammation of 10/Oct/2022
• what: In this study the effect of Smurf1 a kind of E3 ubiquitin ligase in promoting the fibrosis and oxidative stress of LF was investigated and its underlying mechanism was explored.
• how: Similar to the qRT-PCR results western blotting and IHC data showed that the . . .
  

   

  

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