Soft disorder modulates the assembly path of protein complexes

HIGHLIGHTS

  • who: Beatriz Seoane and Alessandra Carbone from the Departamento de Fu0131u0301sica Teou0301rica, Universidad Complutense de Madrid, Madrid, Spain, Sorbonne have published the research: Soft disorder modulates the assembly path of protein complexes, in the Journal: (JOURNAL) of November/17,/2022
  • what: The authors provide statistical evidence for the involvement of highly mobile and disordered regions in complex assembly. Using this database the authors show that upon oligomerisation the new interfaces tend to be observed at residues that were characterised as softly disordered (flexible amorphous or missing residues) in the complexes preceding them in the hierarchy . . .

     

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