HIGHLIGHTS
- who: Claire J. Sarell and colleagues from the Queen Square, London WC N BG, UK have published the research: Soluble Aβ aggregates can inhibit prion propagation, in the Journal: (JOURNAL) of 14/09/2022
- how: The authors used conditions to yield preparations highly enriched in_(i) monomers (ii) pre-fibrillar aggregates known as ADDLs and_(iii) amyloid fibrils.
SUMMARY
Prion diseases are fatal neurodegenerative disorders associated with propagation of multi-chain assemblies of misfolded cellular prion protein (PrPC). To determine if ADDLs could attenuate prion infection, three dilutions of I-BH . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.