Solution structure of cxcl13 and heparan sulfate binding show that gag binding site and cellular signalling rely on distinct domains

HIGHLIGHTS

• who: CXCL and colleagues from the University of Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France have published the Article: Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains, in the Journal: (JOURNAL) of 11/07/2022
• what: The authors report that CXCL13 features a chemokine-like fold to which is appended a non-structured 19-amino-acidlong C-terminal extension. The authors report that such a folding, which would not be compatible with the receptor activation mechanism and would prevent dimerization, is specifically driven . . .
  

   

  

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