Solving the mcm paradox by visualizing the scaffold of cmg helicase at active replisomes

HIGHLIGHTS

• who: Hana Polasek-Sedlackova from the (UNIVERSITY) have published the research: Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes, in the Journal: (JOURNAL)
• what: To avoid extensive changes in the core replisome architecture, the authors focused on TIMELESS, CLASPIN, and AND-1, also known as replication protection complex (RPC), whose depletion for a short period of time only results in a moderate slowdown of replication forks and low levels of DNA damage26. The authors provide a solution to this problem by showing that, in the case of the replication . . .
  

   

  

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