HIGHLIGHTS
SUMMARY
Analyzing 1482 neurons from 10 AD patients and 6 control individuals, the authors reported aneuploid prevalence at 0.7% and 0.6% for control and AD neurons, respectively, and concluded that aneuploid cells are not more common in the AD brain. The study discarded a large fraction of cells (39%) for showing high within-cell variability in genome coverage, although it was unclear to what extent these represented pure technical error versus cells with complex karyotypes. (2) Considerable or even complete loss of NeuN immunoreactivity was also reported for neurons affected by ischemic insults . . .
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