HIGHLIGHTS
- who: Frida Ek from the DepartmentUppsala University have published the Article: Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma, in the Journal: Scientific Reports Scientific Reports
- what: The authors propose that the previously described mitochondrial effects of sorafenib and regorafenib at clinically relevant concentrations translate into potent activity against quiescent cancer cells in 3D models.
SUMMARY
Global gene_expression and galactose experiments indicate similarity between sorafenib and OXPHOS inhibitors. The authors first hypothesized that this mitochondrial effect could elicit an immediate . . .
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